Which team is going to come out on top on Sunday, Sept. 28, when the Detroit Lions and Cleveland Browns square off at 1 p.m. ET? Our projection system sides with the Lions. See our other predictions below, where we break down the final score, spread, and over/under.
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Lions vs. Browns Game Info and TV Channel
- When: Sunday, September 28, 2025 at 1 p.m. ET
- Where: Ford Field in Detroit, Michigan
- TV: FOX
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
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Listen to the game on 97.1 The Ticket
Lions vs. Browns Odds and Betting Info
- Spread favorite: Lions (-10)
- Moneyline: Lions (-595), Browns (+426)
- Total: 44.5 points
Lions vs. Browns Prediction
- Pick ATS: Lions (-10)
- Pick OU: Over (44.5)
Prediction:
Lions 39 - Browns 9
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Lions vs. Browns Betting Insights
- The Lions have covered twice in three games with a spread this season.
- The Browns have won two games against the spread this season.
- Cleveland has not covered the spread this season (0-1 ATS) when playing as at least 10-point underdogs.
- Lions games have hit the over twice this season.
- So far this season, one Browns game has hit the over.
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